Custom Peptides
Cayman Chemical AlIskIrenhemIfumarate 10mg
A nonpeptide renin inhibitor (IC50 = 0.6 nM); reduces blood pressure and prevents albuminuria in renin-overexpressing TG(mRen-2)27 rats in a model of streptozotocin-induced diabetes at 10 and 30 mg/kg
Cayman Chemical VerdIperstat 10mg
An irreversible inhibitor of MPO (IC50 = 630 nM); selective for MPO over a panel of 130 enzymes, transporters, and ion channels (IC50s = >50 µM for all); reduces MPO expression, prevents an increase in neuronal loss, and prevents decreases in motor score and stride length in a PLP-αSYN transgenic mouse model of multiple system atrophy at 180 µmol/kg, p.o.
Cayman Chemical FebrIfugInhydrochlorIde 10mg
A quinazolinone with antimalarial activity; reduces parasitemia and decreases mortality in mice infected with the P. berghei strain NK65 at 1 mg/kg per day
Cayman Chemical CInamyl3 4dIhydroxyaCyn 10mg
A 5-LO inhibitor (IC50 = 15 nM); selective for 5-LO over 12-LO and 15-LO (IC50s = 500 and 300 nM, respectively); inhibits A23187-induced 5-LO product formation in isolated human PMNs, monocytes, and whole blood (IC50s = 0.5, 0.45, and 1.5 µM, respectively); increases survival in a mouse model of PAF-induced lethal shock at 3.5 mg/kg; reduces pleural levels of LTB4 in a rat model of carrageenan-induced pleurisy
Cayman Chemical ArachIdoyl glycIn 10mg
Consists of arachidic acid with glycine attached at its carboxy terminus
Cayman Chemical -Glu-AlatrIfluoroACTAte100mg
A dipeptide; has been found in P. roqueforti; has been found in ripened Gouda, goat, and Milner cheeses; a positive allosteric modulator of CaSR (EC50 = 4.8 µM in CaSR-expressing HEK293 cells); induces glutathionuria in mice at 4 mmol/kg; plasma levels are increased in malnourished neonatal mice; increased serum levels are positively associated with an increased risk of chronic kidney disease
Cayman Chemical Dexamethason PalmItate 10mg
A prodrug form of dexamethasone; binds to the glucocorticoid receptor; reduces LPS-induced increases in cytokine levels in RAW 264.7 macrophages at 100 UG/ml in lipid nanoparticles; reduces paw inflammation and edema in a mouse model of collagen-induced rheumatoid arthritis at 1 mg/kg; inhibits VEGF-induced vascular hyperpermeability for up to nine months in rabbits at 1,280/animal as an intravitreal emulsion injection
Cayman Chemical npIcastathydrochlorIde 10mg
An inhibitor of DBH (IC50 = 9 nM for the purified human enzyme); selective for DBH over a panel of 12 enzymes and 13 neurotransmitter receptors (IC50s or Kis = >10 μM); dose-dependently reduces norepinephrine content and increases dopamine content in the mesenteric artery, left ventricle, and cerebral cortex in spontaneously hypertensive rats, as well as in the renal artery, left ventricle, and cerebral cortex in beagle dogs; attenuates increases in diastolic blood pressure and heart rate induced by preganglionic sympathetic nerve stimulation in pithed spontaneously hypertensive rats at 10 and 30 mg/kg; reduces the progressive ratio response for cocaine, but not food or sucrose pellets, in rats at 50 mg/kg; reduces reinstatement of cocaine-seeking behavior induced by cues, yohimbine, or foot-shock in rats
Cayman Chemical ChoArgtrIfluoroACTAte sal 10mg
A steroid-based cationic lipid; forms a complex with plasmid DNA and decreases plasmid DNA migration in an agarose-gel retardant assay; facilitates transfection of plasmid DNA into H1299 and HeLa cells in the presence or absence of fetal bovine serum; cytotoxic to H1299 cells (IC50 = 88.5 μg/ml)
Cayman Chemical PNU 112455A 10mg
A Cdk2 and Cdk5 inhibitor (Ki = 2 µM for both); inhibits dexamethasone-induced hyperphosphorylation of tau and cell death in PC12 cells expressing human tau at 1 and 10 µM
Cayman Chemical JWH 018 NpropNIc ACD meta 10mg
A major metabolite of JWH 018 that is detectable in urine; this analytical reference standard is intended for forensic and research applications only
Cayman Chemical Glycyza ualns Fsc Glabl 10mg
A flavonoid with diverse biological activities; inhibits NA activity in oseltamivir-sensitive and -resistant H1N1 influenza strains (IC50s = 0.51 and 14.1 µM, respectively), as well as PTP1B, ACAT, and DGAT (IC50s = 0.31, 24.6, and 8 µM, respectively); cytotoxic to MCF-7, SW480, and HepG2 cells (IC50s = 7.62, 5.15, and 2.83 µM, respectively); active against MRSA (MIC50 = 2 UG/ml); binds to the benzodiazepine receptor (Ki = 1.63 µM) and increases pentobarbital-induced sleep duration in mice at 50 mg/kg, an effect that can be reversed by flumazenil
Cayman Chemical FlavokawaIn C 10mg
A chalcone with enzyme inhibitory and anticancer activities; inhibits collagenase and elastase in cell-free assays (IC50s = 62.05 and 17.6 µM, respectively); cytotoxic to HCT116, HT-29, MCF-7, A549, and Ca Ski cancer cells (IC50s = 12.75, 39, 47.63, 40.28, and 39.88 µM, respectively); induces apoptosis and cell cycle arrest at the G1 phase in HCT116 cells at 20, 40, and 60 µM; reduces tumor volume and induces intratumoral necrosis and apoptosis in an HCT116 mouse xenograft model at 1 and 3 mg/kg
Cayman Chemical 1 4-PBITdIhydrobromIde 10mg
1,4-PBIT is a potent inhibitor of purified human iNOS and nNOS with Ki values of 7.4 and 16 nM, respectively, compared to a Ki of 360 nM for human eNOS.{1292} Its inhibition in whole cells is greatly diminished, presumably to poor membrane permeability.