Custom Peptides
Cayman Chemical CIlazaprIlat 10mg
An ACE inhibitor (IC50 = 0.7 nM for the rat enzyme) and active metabolite of cilazapril; decreases creatine kinase release in primary neonatal rat cardiac myocytes in an in vitro model of ischemia-reperfusion injury induced by hypoxia and reoxygenation at 10 µM; increases coronary blood flow and fractional shortening in a dog model of coronary hypoperfusion-induced myocardial ischemia at 3 UG/kg per minute intra-arterially
Cayman Chemical RGyramIde AhydrochLRIde 10mg
A bacterial DNA gyrase inhibitor that disrupts supercoiling activity (IC50 = 3.3 µM); demonstrates antibacterial activity against E. coli, P. aeruginosa, and S. enterica (MICs range from 10-80 µM)
Cayman Chemical T2AAhydrochlorIde 10mg
An inhibitor of PCNA; inhibits protein-protein interactions between PCNA and a PIP-box-containing peptide (IC50 = 1 μM) as well as full-length p21; reduces cellular colocalization of PCNA and DNA polymerase δ; inhibits DNA replication and cell growth in U2OS and HeLa cells; induces cell cycle arrest at the S phase at 20 μM; increases cisplatin-induced DNA double strand break formation in a neutral comet assay and inhibition of clonogenic survival in HeLa and U2OS cells
Cayman Chemical Lentztrehalose C 10mg
A disaccharidemicrobial metabolite with autophagy-inducing activity; induces autophagy in MeWo and OVK18 cells at 100 mM
Cayman Chemical ChIcorIc AcId 10mg
A dicaffeoyl ester with diverse biological activities; reduces the viability of Caco-2 and HCT116 colorectal cancer cells from 50-200 μg/ml; inhibits the 3'-processing and DNA integration activities of HIV integrase (IC50s = 1.1 and 0.8 μM, respectively); inhibits HIV entry into H9 cells at 5 μM; oral administration reduces hepatic lipid accumulation, lipid peroxidation, and fibrosis, inhibits production of pro-inflammatory cytokines and activation of NF-kB, and activates the AMPK signaling pathway in a mouse model of NASH induced by a methionine and choline-deficient diet at 10 and 30 mg/kg; reduces blood glucose levels by 54% in mice with streptozotocin-induced diabetes at 2 mg/kg
Cayman Chemical ncrostatIn-2 10mg
A potent inhibitor of necroptosis (EC50 = 50 nM); 4-fold more active than the (S)-enantiomer (EC50 = 230 nM)
Cayman Chemical NarlaprevIr 10mg
An HCV NS3 inhibitor (Ki = 6 nM); also inhibits SARS-CoV-2 Mpro (IC50 = 16.11 µM); inhibits HCV replication in a cell-based replicon assay (EC90 = 40 nM) and SARS-CoV-2 replication in Vero cells (EC50 = 7.43 µM)
Cayman Chemical UK 122trIfluoROCTAte salt 10mg
A uPA inhibitor (IC50 = 0.2 µM); selective for uPA over tPA, trypsin, plasmin, and thrombin (IC50s = >100 µM for all); inhibits the migration and invasion of CFPAC-1 cells at 100 µM; prevents glutamate-induced phase shifts in isolated suprachiasmatic nucleus slices from tPA-/- but not wild-type mice at 0.2 µM; decreases disease severity and colorectal levels of RANTES in a mouse model of DSS-induced colitis at 4 mg/kg
Cayman Chemical ACTH11-24humnmouser 10mg
A peptide fragment of ACTH and an MC2R antagonist (IC50 = ~1 nM in HeLa cells expressing the mouse receptor); induces corticosterone and aldosterone production in isolated rat zona glomerulosa and zona fasciculata cells, respectively, with minimum effective concentrations of 4 and 3 µM, respectively; inhibits ACTH-induced stretching, yawning, and penile erections in rats at 1.69 UG/animal, i.c.v.
Cayman Chemical ArylpIperazIn 5k 10mg
A FATP1 inhibitor (IC50 = 4.6 nM for the human protein); reduces neutral and polar lipid accumulation induced by linoleic acid in MDA-MB-231 cells at 12.5 µM; decreases ATP and BODIPY-palmitate levels in CD37-/- knockout BJAB cells but not in wild-type BJAB cells at 12.5 µM; induces cell death in MDA-MB-231, MCF-7, HCC1806, and BT474 cells at 12.5 µM
Cayman Chemical GlepaglutIdeacetate 10mg
A peptide; agonist of GLP-2R; selectively induces cAMP accumulation in HEK293 cells expressing GLP-2R over those expressing GLP-1R (EC50s = 0.24 and 8.7 nM, respectively, for the human receptors); increases mucosal hyperplasia thickness in the duodenum, jejunum, and ileum, as well as increases small intestinal wet weight and length, in rats at 10 mg/kg per day for 26 weeks; increases small intestinal mass and length, as well as reduces ileal levels of AGP 1 and MPO, in an indomethacin-induced rat model of IBD at 400 nmol/kg twice per day
Cayman Chemical SWAY100135hydrochLRIde 10mg
A 5-HT1A antagonist (IC50 =15.5 nM in a radioligand binding assay); selective for 5-HT1A over 5-HT1B, 5-HT1C, and 5-HT2 receptors, as well as dopamine D1 and D2, and α1-, α2-, and β-adrenergic receptors (IC50s = >1 µM for all); increases the number of entries into and percentage of time spent in the open arms of the elevated plus maze in mice at 10 mg/kg.
Cayman Chemical -CloprostenolsodIum salt 10mg
(±)-Cloprostenol (sodium salt) is a more water solute, crystalline form of cloprostenol than the free acid.
Bachem (D-Ala2)-Gastric Inhibitory Polypeptide (human) Trifluoroacetate
(D-Ala2)-Gastric Inhibitory Polypeptide (human) Trifluoroacetate, H-Tyr-D-Ala-Glu-Gly-Thr-Phe-Ile-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-Ile-His-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-Gly-Lys-Lys-Asn-Asp-Trp-Lys-His-Asn-Ile-Thr-Gln-OH, 444073-04-5, C226H338N60O66S, Mr 4983.53, 0.5mg. (D-Ala2)-GIP (human), [DAla2] Gastric Inhibitory Peptide (GIP), human. GIP receptor agonist.