Custom Peptides
Cayman Chemical AcetamIprId 10mg
A neonicotinoid insecticide; an agonist of insect nAChRs; activates nAChRs containing N. lugens α1 and rat β2 subunits (EC50 = 67 µM in X. laevis oocytes); leads to sexual and aggressive behaviors in adult male offspring after administration to pregnant mice (1 mg/kg); decreases anxiety-like behavior of adult male offspring in the light-dark transition test (1 and 10 mg/kg)
Cayman Chemical IACS-010759 10mg
An orally bioavailable inhibitor of mitochondrial complex I; inhibits the ubiquinone reduction activity of isolated murine mitochondrial complex I at 60 nM; reduces basal and spare respiratory capacities and increases glycolytic flux in primary CLL cells at 100 nM; induces apoptosis in CLL cells grown under low glucose conditions or when administered in combination with 2-deoxy-D-glucose; induces tumor regression in a glycolysis-deficient NB1 mouse xenograft model when administered at doses of 5 and 10 mg/kg
Cayman Chemical ValerylLcarnItInchLRIde 10mg
A short-chain acylcarnitine; levels increase in the serum of rhesus monkeys following exposure to 7 and 10 Gy of ionizing radiation
Cayman Chemical 3hydroxy StarIc ACD mthyl 10mg
A hydroxy fatty acid methyl ester; has been found in PHA polymers produced by Streptomyces sp. JM3 and in trace amounts in M. bijuga fruit; chemical scent constituent in feces of adult wild Iberian wolves (C. lupus signatus)
Cayman Chemical DapnsutrIle 10mg
An NLRP3 inflammasome inhibitor; inhibits the release of IL-1β and decreases caspase-1 levels in LPS-stimulated J774A.1 murine macrophages, HMDMs, and primary human blood neutrophils; selective for NLRP3 over NLRP4 and AIM2 inflammasomes at concentrations up to 100 μM; inhibits ASC oligomerization and NLRP3 association with caspase-1 and ASC in LPS- and nigericin-stimulated J774A.1 cells; reduces MPO, CXCL1, and IL-6 levels in peritoneal fluid as well as IL-1β levels in liver, lung, spleen, and skeletal muscle in a mouse model of LPS-induced systemic inflammation; increases markers of oxidative metabolism in muscle in mouse model of LPS-induced systemic inflammation; reduces IL-1β release in blood monocytes isolated from patients with CAPS
Cayman Chemical PAR21-6mouserat 10mg
A peptide agonist of PAR2; induces relaxation in precontracted rat arteries; inhibits keratinocyte growth in the presence and absence of growth factors; inhibits LPS-induced pulmonary neutrophil influx and increases in MMP-2 activity in mice
Cayman Chemical HeparInbIndng PeptIdetrIf 10mg
A peptide fragment of fibronectin; induces focal adhesion formation in pre-spread HEFs from 1-1,000 UG/ml; inhibits HBFN-f-induced production of MMP-1, MMP-2, and MMP-9 in isolated human articular cartilage; has been used in peptide surface micropatterning for surface endothelialization
Cayman Chemical 1 2DIlInoleoylsnglycero3 10mg
A phospholipid containing the polyunsaturated long-chain (18:2) linoleic acid inserted at the sn-1 and sn-2 positions
Cayman Chemical JWH 018 NpropNIc ACD meta 10mg
A major metabolite of JWH 018 that is detectable in urine; this analytical reference standard is intended for forensic and research applications only
Cayman Chemical CyclothIazIde 10mg
A benzothiadiazide that acts as a potentiator of AMPA receptors, positively modulating its response to glutamic acid (EC50 = 3.8 µM); also a negative modulator of GABAA receptors, reversibly inhibiting both evoked and spontaneous inhibitory postsynaptic currents (IC50 = 58 µM)
Cayman Chemical 6-hydroxy Bexaroten 10mg
An oxidative metabolite of bexarotene; binds to RXRα, RXRβ, and RXRγ as well as RARα (Kds = 3.46, 4.21, 4.83, and 8.17 μM, respectively); selectively activates RXRα, RXRβ, and RXRγ over RARα, RARβ, and RARγ in vitro (EC50s = 398, 356, 420, 4,414, 2,121, and 2,043 nM, respectively)
Cayman Chemical SynthetIc Curzeren 10mg
A sesquiterpene with diverse biological activities; scavenges DPPH radicals in a cell-free assay at 3.36 UG/L with a synergistic effect when used in combination with eucalyptol; active against F. graminearum at 0.5 mg/ml; inhibits the proliferation of SK-MEL-19 melanoma cells (IC50 = 5.17 UG/ml), as well as AGP-01 gastric and HCT116 colon cancer cells (IC50s = 8.04 and 9.18 UG/ml, respectively) and MRC-5 non-cancerous human fibroblasts (IC50 = 11.45 UG/ml); induces apoptosis in, and decreases migration of, SK-MEL-19 cells at 5 and 10 µM; reduces tumor weight in an SPC-A1 mouse xenograft model at 135 mg/kg
Cayman Chemical 6-ChrysenamIn 10mg
A carcinogen and anticancer agent; neonatal administration induces the formation of hepatomas and pulmonary adenocarcinomas in adult mice at 600 UG/animal; s.c.; inhibits tumor growth in an EO771 murine mammary carcinoma model from 3-110 mg/kg
Cayman Chemical PeonIdInchlorIde 10mg
An O-methylated anthocyanidin that exhibits chemopreventive as well as anti-inflammatory activities on cancer cells in vitro, blocking COX-2 expression and transformation in JB6 P+ mouse epidermal cells